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Well start with the most obvious one

The honest answer is that we don't know for certain

Results Directly relevant to its use as a PD therapeutic is the capacity of Dihexa to act synergistically to protect neurons from general growth factor deprivation (Figure 46) and oxidative stress (Figure 47), the underlying cause of neuronal cell death in PD

A key observation was the production of anti-cagrilintide antibodies, with increased incidence correlating with higher doses and prolonged exposure, affecting 46% to 73% of participants by week 26