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In Asian populations, such as this family of sisters, the HFE mutation is rarely detected, making awareness of FD in patients with features of genetic iron overload important

Furthermore, research indicates that CPS1, the key enzyme in the urea cycle, is predominantly expressed in hepatocytes and certain renal cells, with low or absent expression in most immune cells due to the urea cycles inactivity in these cells (134, 135)

Tryptophan deprivation results in diminished proteosynthesis and decreased activation of the rapamycin pathway, perhaps contributing to polyneuromyopathy [71]

Targeting key signaling pathways associated with SR activationsuch as MAPK, NF-B, and JAK-STAThas been explored in clinical trials with mixed outcomes, largely due to SLE's intrinsic heterogeneity and overlapping immunopathogenic mechanisms (316, 372, 373)

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