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Upon binding to the peripheral neuronal presynaptic membrane mediated by the heavy chain the toxin is internalized by receptor-mediated endocytosis

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For example, the role of EAAT3 was explored in brain tumour models, but the studies focused on glutamate transport and the central nervous system-specific glutamatergic cycle, 35,36 which is essential for the ultimate production of neurotransmitters

Applied in liposomal form to burn wounds in mice, this complex promoted angiogenesis and shortened healing time

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