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Curcumin downregulates the inflammatory cytokines CXCL1 and -2 in breast cancer cells via NFkappaB

PF prevented the upregulation of pro-inflammatory mediators (TNF-, IL-1b, iNOS, COX2, and 5-LOX) in plasma and brain to the sustained activation of hippocampal AST and microglia caused by chronic cerebral insufficiency of cerebral perfusion or cerebral ischemia, suggesting that PF exerts delayed protective effects in ischemia-injured rats by inhibiting the peripheral and cerebral tissue inflammatory responses mediated in MAPKs/NF-kB (Guo et al., 2012

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The recommended dosing regimen involves an initial 284 mg subcutaneous injection, followed by another injection at 3-month, and subsequent injections every 6 months thereafter (Ray et al., 2023)

Handschin C, Spiegelman BM