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So the "vs" here is really a comparison between a fat-cell-targeting fragment and gut-hormone-mimicking peptides

Self-administered B12 shots are generally recommended for individuals: whose bloodwork has documented low B12 levels Patients with pernicious anemia or a lack of intrinsic factor Individuals with Crohn's disease, celiac disease, or post-bariatric surgery malabsorption Vegans and strict vegetarians are unable to correct the deficiency through diet Older adults whose stomach acid production has declined with age Anyone on long-term metformin or proton pump inhibitors Across most of the U.S., injectable B12 is not sold over the counter a clinician has to write the script before a pharmacy can dispense it

They might help you if: You already know you have a B12 deficiency

Vitamin C can make your urine more acidic

This means active individuals are more susceptible to functional B vitamin depletion even when following an otherwise balanced diet

The absence of FDA approval means that use represents an off-label application requiring informed consent and medical judgment