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Histopathological analysis revealed that follicle development was blocked at an early stage in the treatment group relative to the control group, and a large number of atresia and abnormally developed follicles were observed (Fig

This is particularly relevant as the BBB represents a major challenge in CNS drug delivery, often preventing neurotherapeutic agents from effectively reaching the brain

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In the U.S., zinc deficiency is unusual, as most people receive sufficient zinc from foods as varied as meat, fish, fortified cereals, beans, eggs, nuts, and dairy products

Researchers considering extended protocols should be aware that this safety gap exists and should monitor for unexpected effects in tissues where NNMT has normal physiological functions