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Effects of HOCl on the host environment Role of extracellular MPO in host tissue damage There is little doubt that MPO-generated hypohalous acids, particularly HOCl, are of crucial importance for microbial killing

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Gentiopicroside improves dss-induced ulcerative colitis and secondary liver injury in mice by enhancing the intestinal barrier and regulating the gut microbiome

To ensure accurate results and avoid potential issues related to partial proteolysis, inherent flexibility, and conformational heterogeneity, we utilized the human ABCB6 core region lacking TMD0 (hABCB6 core ) for our experiments 37

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Moreover, IL-17A and TNF- act synergistically to drive a marked upregulation of the chemokines CCL20 and CXCL8 sustaining leukocyte recruitment [4, 84]