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Curiously, in 1984 it was recognized that the actual reasons for the electron density missing from a protein structure can be very different (Garner et al., 1998)), i.e., the wholesale movement of a structured domain facilitated by a flexible hinge

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Certain factors increase your risk of developing a B12 deficiency, including: restrictive diets low in B12 autoimmune diseases and some other health conditions age of 60 or older certain medications (like Metformin and Prilosec) gastrointestinal surgery Although its rare, severe B12 deficiency can result in irreversible damage to your nervous system