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If this is high, it is a sign of poor phase II liver detoxification, and you want to boost glycine or reduce salicylates and benzoates

doi: 10.1016/j.nbd.2015.05.009 356 Halon-GolabekMBorkowskaAHerman-AntosiewiczAAntosiewiczJ

It's simpler than it looks

Study of Vitamin C Pharmacology The intravenous administration of high dose ascorbate (IVC) has increased in popularity among complementary and alternative medicine practitioners: thousands of patients received IVC, at an average dose of 0.5 g/kg, without significant side effects

Probably, as a relatively small protein without multi-domains, its unfolding followed a simple path, and it remained active until heat-induced aggregation