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10.1186/1755-1536-1-6 4 AmicF.DrmicD.BilicZ.KrezicI.ZizekH.PeklicM.et al (2018)

These models lack the matrix and immune cells essential for regulating cell behaviors, such as differentiation, survival, proliferation, and migration, making it impossible to accurately simulate the organ structure (55)

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This sets it apart from semaglutide and tirzepatide, which target only one or two of these receptors