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Bjursell M, Gerdin AK, Jnsson M, et al

When looking at data from clinical trials, ALA has revealed to be efficient in particular diseases and conditions, including diabetic neuropathy, obesity, schizophrenia, MS, abnormalities in pregnancy and organ transplantation, with no or minor adverse effects

64 :e202502187 242

Mitochondrial JNK activation triggers autophagy and apoptosis and aggravates myocardial injury following ischemia/reperfusion

Over time, MGO first leads to an increased activation of c-Jun protein through JNK phosphorylation, which then lead to pro-inflammatory cytokine production [115]