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We further hypothesized that melatonin supplementation could improve the success rate of ART by increasing the quality of oocytes and embryos, increasing pregnancy rates, reducing oxidative stress, and promoting overall reproductive health

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Kowdley KV, Bowlus CL, Levy C, Akarca US, Alvares-da-Silva MR, Andreone P, Arrese M, Corpechot C, Francque SM, Heneghan MA, Invernizzi P, Jones D, Kruger FC, Lawitz E, Mayo MJ, Shiffman ML, Swain MG, Valera JM, Vargas V, Vierling JM, Villamil A, Addy C, Dietrich J, Germain JM, Mazain S, Rafailovic D, Tadd B, Miller B, Shu J, Zein CO, Schattenberg JM, The New England journal of medicine 2023 Nov Open-label, clinical trial extension: Two-year safety and efficacy results of seladelpar in patients with primary biliary cholangitis