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Patients must exhibit two or more of the specified symptoms for a duration of 1 month

Idiosyncratic drug reactions

Scholar de Thonel A, Vandekerckhove J, Lanneau D

Due to aging-associated electron leakage from the respiratory chain and elevated ROS levels, mtDNA is particularly vulnerable to oxidative insult

141 Studies have proven that peripherally injected LPS increases the central and peripheral metabolism of TRP via the KYN pathway by exerting neurotoxic effects, inducing reactivation of microglia and astrocytes in the CNS

Its biological influence spans across the musculoskeletal, gastrointestinal, and neurological systems