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Nevertheless, knockout of p53 or p21 paradoxically accelerates gastrointestinal damage and death, indicating that p53 may have a bidirectional effect in radiation-induced injury (198)

Despite the availability of multiple chemotherapeutic options, clinical efficacy remains limited due to poor drug solubility, restricted intestinal absorption, rapid systemic clearance, and multidrug resistance

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631,632 Cao et al

Herkenham M, Lynn AB, Little MD et al (1990) Cannabinoid receptor localization in brain

Jin believed that proteins that mimic these cytokine receptors could help combat cytokine storms, which can be produced by viral or bacterial infections, including HIV and hepatitis