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However, a controversial issue is that it has not been proven that lowering Hcy by B vitamins supplementation can reduce the risk of cardiovascular disease

while excessively high levels of ROS causing lipid, protein and DNA cell damage are known as oxidative stress (Schieber and Chandel, 2014)

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This compound is a cyclic hydroxylamine that is oxidized upon the reaction with superoxide to generate a more stable radical called nitroxide