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Although high dose supplementation of glutamine at 500 or 1000 mg/kg caused prevention of weight loss, no significant weight loss or gain was reported in these studies

483 This suggests that targeting CaSR could potentially provide a more effective therapeutic strategy by avoiding the adverse effects of these blockers in IPAH patients, who often have upregulated CaSR activity

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doi:10.1038/embor.2008.227

H., and Bardien S., Curcumin PreTreatment May Protect Against Mitochondrial Damage In LRRK2Mutant Parkinson's Disease and Healthy Control Fibroblasts, Biochemistry and Biophysics Reports 27 (2021): 101035