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When it becomes oxidized, it can break down yielding a large variety of compounds including a, -unsaturated aldehydes (Poli et al., 1987) These are toxic compounds because they can react with proteins in the cells, particularly at cysteine, lysine or histidine by either Michael addition to the carboncarbon double bond or by Schiff base formation at the carbonoxygen double bond (Esterbauer et al., 1991

Hence, comprehensive exploration of potential mechanism of Cu homeostasis in disease development, and in-depth study of Cu homeostasis-associated regulatory pathways under different pathological areas have grand medical value and translational significance

10.1073/pnas.1711235114 70 CersosimoM

Bile-ology: from bench to bedside

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