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SURF1 deficiency is a monogenic mitochondrial disorder and the most common cause of cytochrome c oxidase-deficient LS

Interestingly, when we compared our cryo-EM model to the isolated crystal structure of ENL (PDB: 6HQ0), we observed an inward movement of the loop containing ENL-Q41 (amino acids 37-42, backbone RMSD = 1.9), which is wedged into a groove formed by the CRBN N-lobe (Extended Data Fig

The prominent ribosomal decay occurring in ACT-treated WT cells was partially rescued in the ATP6AP1 KO cells at both steady-state and native assembly (Fig

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Alzheimers Res Ther 2020;12(1):157-157 Ji Won Han, Pauline Maillard, Danielle Harvey, Evan Fletcher, Oliver Martinez, David K Johnson, John M Olichney, Sarah T Farias, Sylvia Villeneuve, William Jagust, Dan Mungas, Charles DeCarli Association of vascular brain injury, neurodegeneration, amyloid, and cognitive trajectory

Our exploration of cutting-edge methods, such as causal inference and multi-omics fusion, may be insufficient