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Drug-metabolising enzymes (DMEs) play an important role in scavenging the waste products of lipid metabolism and oxidative metabolism and maintaining homeostasis of liver 4,5 , consisted of groups of enzymes, such as glutathione S-transferases (GSTs)

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p62 activators Two compounds able to increase p62 levels, trehalose and rapamycin, have been demonstrated to increase nuclear translocation of NRF2 in a p62-dependent manner and to enhance expression of its downstream antioxidant factors, HO1 and NQO1, in a hepatoma cellular system [308] and in a preclinical model of FRDA [309]

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According to another hypothesis, the immune system has successfully vanquished the infection but remains stuck in a faulty state