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The literature mining of scientific databases showed that more than 20,000 papers have been published on different classes of AFs from 1990 to 2021

Disruption of the circadian clock results in loss of rhythmic chaperonemediated autophagy activity and significant changes in the chaperonemediated autophagydependent cellular proteome [118]

SIRT7 Sirt7 is also highly expressed in HSC, which exerts its regenerative ability by regulating the unfolded protein response in mitochondria

A decrease in SOD2 leads to the accumulation of ROS in mitochondria, which in turn disrupts membrane potential and inhibits respiratory chain activity, forming a vicious cycle of ROSmitochondrial damagemore ROS

Gastrointestinal Cancers Program

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