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Concurrently, loss of Treg-mediated suppression permits Th17 activation and IL-17 release, driving robust neutrophil recruitment and destructive inflammation that promotes a more severe and refractory disease phenotype

Safety concerns can differ by route (U.S

doi: 10.1186/s13568-025-01824-6 113 FanX.ChenL.ChenM.ZhangN.ChangH.HeM.et al

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Using high-throughput screening, we subsequently identify AG1, a small molecule that increases the activity of the wild-type, the Canton mutant and several other common G6PD mutants

Cancer 122 , 4252 (2019)