acetyl-l-carnitine and alpha lipoic acid dr weil+ Acetyl L-Carnitine & Alpha-Lipoic Experts weigh in on which

Solleiro-Villavicencio H, Rivas-Arancibia S

They have discovered that polyphenols may exhibit the ability to scavenge free radicals through (1) direct reaction with reactive oxygen species (ROS), (2) enhanced dismutation of free radicals to compounds with much lower reactivity, (3) inhibition of catalase enzyme activity, (4) increased activity of antioxidant enzymes such as SOD, (5) chelation with pro-oxidative metals like iron and copper, and (6) increasing the effectiveness of other small antioxidants like tocopherols and ascorbic acid [208, 209]

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20 Medication and Substance Use

Additionally, the diet reduces the expression of microglial activation markers (e.g., Iba1, CD11b), mitigating neuroinflammation, with its protective effects independent of amyloid- plaque reduction, thus offering new targets for intervening in early cognitive dysfunction (Di Lucente et al., 2024)

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