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Concomitantly, expanded adipose tissue synthesizes and secretes huge amounts of cytokines and chemokines, collectively defined adipochemokines or adipokines, such as leptin, that promote infiltration of adipose tissue by macrophages with subsequent overproduction of RO(N)S and inflammatory cytokines, leading to adipose tissue inflammation (21, 22)

Erythrocytes play a crucial role in the regulation of eNOS-derived nitric oxide (NO) bioavailability, acting as scavengers of this critical vasodilator with an effect on vascular tone and blood flow [45]

For instance, LePHGPX in transgenic tobacco plants protected against DNA fragmentation, membrane integrity loss, and oxidative stress induced by necrotrophic fungi, mirroring anti-apoptotic roles observed in animals ( Ferroptosis, a form of iron-dependent lipid peroxidation-mediated cell death, was first described in animals and is regulated by GPX4 (Seibt et al., 2019

[11] Two magnesium ions function to stabilize the acylphosphate intermediate, facilitate binding of ATP, and activate removal of phosphate group from ATP

While DFP has demonstrated the capacity to reduce mitochondrial iron overload and mitigate oxidative stress in preclinical models, its clinical application highlights a critical challenge

doi: 10.1016/0024-3205(81)90374-x 199 GirottiAWThomasJPJordanJE