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CAP acts on the large ribosomal subunit (LSU) by inhibition of peptide bond formation, thereby stalling mitoribosomes resulting in loss of mitochondrial translation with subsequent loss of mitochondrial-encoded respiratory chain complexes (Figs

In this context, radio- and chemo-resistant GSCs present a metabolic adaptation presenting a reduced glucose dependence, an improved lipid catabolism, ROS, mitogen-activated protein kinases (MAPKs) activity, and NAD + level, and an amplified SIRT1/PGC1 axis that promotes autophagy, resulting in an increase in the maintenance and repair machinery (Ye et al., 2013)

It is recommended 4 that samples be processed as soon as possible because GSH is rapidly metabolized and will continue to form various disulfides

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