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mean age 40[SD 11.1], 59% female): 37 presymptomatic mutation-carriers (no symptomatic ICH), three symptomatic mutation-carriers (one symptomatic ICH), eight 50%-at-risk participants and 18 controls Among 37 presymptomatic mutation-carriers, 23(62%) had WMH in a multi-spot pattern, 28(76%) severe CSO-EPVS, 17(46%) microbleeds, and 8(22%) macrobleeds

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PQQ may secure metabolic homeostasis by regulating lipogenesis and lipolysis

doi: 10.1038/sj.ijo.0803695

ROS-related mitochondrial dysfunction in skeletal muscle of an ALS mouse model during the disease progression