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The investigators followed the patients for 51 months

The PS-TREM2 signaling pathway is crucial for synaptic refinement in brain regions such as the hippocampus and dorsal lateral geniculate nucleus, where pruning is essential for proper circuit maturation (158, 179)

1, 2, and 3-ARs, which are coupled to G s , lead to activation of adenylyl cyclase, increasing levels of the second messenger cyclic AMP (cAMP) to promote Protein kinase A (PKA) activation (83) (Figure 2)

Oxygen consumption rate (OCR) analysis was performed on a Seahorse XF Pro Analyzer (Agilent Technologies, Santa Clara, CA, USA) using the Seahorse XF Cell Mito Stress Test Kit (Agilent Technologies) to detect mitochondrial respiratory function in cardiomyocytes