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Though for decades ACs were thought to be only a transport form of acyl-moieties into mitochondria, recent studies have elucidated the active role of ACs in the regulation of energy metabolism and proposed AC accumulation as a link to insulin resistance 15,26,30,31

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It is possible that these variants have impaired folding and localisation, although R169W has previously been shown to localise normally to the membrane 53

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Obstructive cases often yield more viable sperm, boosting rates by 15%