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References Ayala A, Muoz MF, Argelles S (2014) Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal

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In the adult human brain, tau consists of six isoforms, produced by alternative mRNA splicing of the MAPT gene located on chromosome 17q21.31, and the tau gene contains 16 exons

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These dualities can imbalance cell fate, either toward cell death or toward survival, depending on the cell type, the metabolic state and the ability to detoxify