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Since tyrosinase-catalyzed reaction is highly associated with local hyperpigmentaiton such as ephelide, melasma and lentigo 5 , discovering of tyrosinase inhibitors are of great importance in cosmetic and medicinal products for the prevention of pigmentation disorders 12

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While several IgG Fc variants with increased plasma half-life have been developed, and some have successfully reached the clinic 23,24,25,36,53,54 , few have been Fc-engineered by a small number of amino acid substitutions that increase plasma half-life, improve biodistribution and specific effector functions, such as complement activity

doi: 10.1007/s10753-021-01504-0 141 YangXZWeiW