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To shield cancer cells from therapeutic action, TAMs also secrete a variety of soluble factors into TME, such as interleukins, chemokines, etc

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Here, we focus on ATP signaling, which is relevant to epithelial cells, and nitric oxide (NO) signaling, which tends to be perturbed in endothelial cells [70]

Abcam), zona occludens-1 (ZO-1

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