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La vitamina B12 baja tiene asociaciones recientes con cuadros de migraa crnica, y una homoscistena alta, con los cofactores bajos y alteraciones en la MTHFR (recordemos, la que permita el paso de THF a M-THF), se ha visto relacionado con la migraa con aura, por una incorrecta sntesis de metionina, que acaba derivando en aumento de homocistena y sta provocando un aumento de las especies reactivas de oxgeno (provocando estrs oxidativo)

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