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History A careful history will help establish the diagnosis and formulate a treatment plan

The spectrum of irAEs Cutaneous toxicities are the most common irAEs resulting from ICI therapy and often present as a distinct pruritic maculopapular rash, commonly seen on the trunk and the limbs, exacerbated by underlying psoriasis

Dosing of NAC can be continued if the serum paracetamol level is above 10 g/mL or if alanine aminotransferase (ALT) elevation persists, especially in the setting of acidosis, coagulopathy, acute kidney injury and hyperbilirubinemia as these patients have worse outcomes[71]

Compounded GHK-Cu preparations would be mixed by a licensed pharmacy under prescriber direction for an individual patient, an activity Health Canada has flagged as outside permitted scope for unauthorized injectable peptides, with GHK-Cu specifically named in seizure advisories