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4.4 Blocking the formation and evolution of DTP cells DTP cells possess high phenotypic plasticity, enabling them to flexibly alter their phenotype and function according to microenvironmental conditions (101, 144, 145).This characteristic allows DTP cells to adapt and evolve various drug resistance mechanisms under therapeutic stress, significantly increasing the difficulty of AML treatment

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In fact, mitochondria contain a large number of proteins, from those involved in energy metabolism, solute transport, ROS production, to inducers of apoptosis, antioxidant defense, and those responsible for mitochondrial dynamics, that are targeted by S-glutathionylation

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10.1097/00003246-200209000-00011 Oudemans-van Straaten HM, Bosman RJ, Treskes M, van der Spoel HJ, Zandstra DF: Plasma glutamine depletion and patient outcome in acute ICU admissions