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Model building and refinement The initial apo-GLS2 model was adapted from the PDB entry 4BQM for the catalytic domain and 5U0K for the ankyrin repeats

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Increases SIRT-1 activity as a result of enhanced NAD+ salvage, leading to beneficial epigenetic and metabolic reprogramming, including increased oxidative phosphorylation (OXPHOS) and muscle stem cell activation 1-3

the extent to which the description may vary will depend on how great a change can be instituted and still have one of ordinary skilled in the art recognize the modified feature as still having the required characteristics and capabilities of the unmodified feature

Julamanee, J

The elevated cost of this particular treatment and the route of administration have a significant impact on the adherence of patients to this pharmacological alternative