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Many experts recommend using these on alternate nights or in separate routines (for example, acids or strong vitamin C in the morning and copper peptides at night) to maintain efficacy and a strong skin barrier

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J Physiol Sci 66(2):113125 Li HT, Jiao M, Chen J, Liang Y (2010) Roles of zinc and copper in modulating the oxidative refolding of bovine copper, zinc superoxide dismutase