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The activation of the cGAS/STING pathway causes ROS accumulation and mitochondrial damage and promotes the migration and invasion of RA-FLSs, a process associated with the activation of the Hippo pathway

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4c,d), which is consistent with their close evolutionary relationship (Fig

Aviram M, Billecke S, Sorenson R, Bisgaier C, Newton R, Rosenblat M, Erogul J, Hsu C, Dunlop C, La Du B

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coli isozyme in the RCSB PDB, including structures of true reaction intermediates.[21, 22] A majority of the mechanistic insight gained from studying AAT has been applicable to other PLP dependent enzymes, especially aminotransferases.[12, 17, 2335] In recent years, we have again turned to AAT to test basic ideas in PLP and protein chemistry