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Results: Meta-analysis showed a statistically significant effect of curcumin on depressive symptoms (SMD: 0.65, P = 0.01, 95% CI: 1.16 to 0.13, I 2 = 93%) and anxiety symptoms (SMD: 0.22, P = 0.01, 95% CI: 0.40 to 0.05, I 2 = 0%)

Long ago has it been known that angiotensin II is frequently elevated in hypertense people and associated to high levels of free radicals in oxygen which increase renal damage (42) and therefore, natural antioxidants like bilirubin have protector effects (figure 3)

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reported a decreased expression of CLOCK, CRY1, PER1, and PER2 in the peripheral blood mononuclear cells of 326 PD patients compared to their healthy controls, along with a decreased concentration of melatonin [434]

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