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doi: 10.3389/fneur.2018.01033 175 BerentschotJCDrexhageHAAynekulu MershaDGWijkhuijsAJMGeurtsvanKesselCHKoopmansMPGet al

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Here, we show that reversing the hypoxic tumor microenvironment by continuously catalyzing endogenous H 2 O 2 into O 2 to elevate the intratumoral sO 2 level can increase the in vivo biosynthesis of PpIX through the regulation of PpIX-related synthetases