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It also has an antioxidant effect by stimulating the antioxidant enzyme superoxide dismutase and preventing the release of oxidation-promoting iron

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TSHR Y444X patient received L-T4 treatment since the 10 th day of life and were physically normal afterwards 10 , however, Tshr null mice will die within a week after weaning without L-T4 treatment 13

There are theoretical concerns, like a potential connection to cancer, that can't be dismissed without more research

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