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Combined treatment with low doses of the SIRT1-specific activator SRT2104 and the LDHA inhibitor oxamate exerted significant antitumor effects on GC cells, with limited adverse effects on normal gastric cells

The poor prognosis of GBM is largely attributable to the highly infiltrative nature, extensive heterogeneity, and strong resistance to conventional therapies associated with the disorder

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Resveratrol-dependent SIRT1 activation reduces p53 activation and microglial activation

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In fact, continuous application may be necessary to maintain benefits, similar to other hair restoration treatments