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Discovered in 2015 at USC, early studies showed it prevents diet-induced obesity in mice by enhancing fat oxidation

COX-2 inhibition improves immunotherapy and is associated with decreased numbers of myeloid-derived suppressor cells in mesothelioma

Furthermore, the researchers attempted to induce a senescence-like state in a testosterone-producing cell line using oxidative stress, FOXO4 shifted into the nucleus, and senescence pathway markers increased

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