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Description

The closed form of ME2 is a pentary complex with natural product pyruvate, cofactor NAD + , Mn 2+ , and fumarate 3,43

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It has been reported that Beclin1 also interacts with Bcl-2 [96]

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Knockout of circ0097009 lead to decreased expression of SLC7A11, inactivation of GPX4 and a decrease in GSH/GSSG ratio, all of which result in increased sensitivity to ferroptosis (175)