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43 Other studies in women link glutathione deficiency to premature ovarian aging and even ovarian cancer, while higher follicular glutathione levels have been tied to increased IVF fertilization rates

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Protein Kinases Modulation Protein kinases such as ERK, AMPK, GSK3, p38 MAPK, and PI3K/AKT can mediate Nrf2 phosphorylation which enhance Nrf2 stability, thereby promoting nuclear Nrf2 translocation and transactivation activity (Nguyen et al., 2003