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In DBA2J mice, where glaucomatous-like ON pathology is directly linked with failure of mitochondrial bioenergetics and decreased Ngb content, exogenous delivery of Ngb can slow down progression of RGC degeneration or even reverse it, which brings up a promising application in mitochondrial ON diseases, i.e., LHON ( Estrogens and Their Receptors Estrogens are steroid hormones primarily related to the reproductive, skeletal and cardiovascular systems (Munaut et al., 2001)