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SCFAs produced by microbiota affect mitochondrial function, for example, the lack of butyrate led to a significant reduction in nicotinamide adenine dinucleotide (NAD), resulting in autophagy in germ-free mouse colon cells [30]

EPIC: A tool to estimate the proportions of different cell types from bulk gene expression data

In its role as a redox buffer, GSH is conjugated to reactive Cys of endogenous proteins, inducing conformational changes in the substrate proteins, and effecting a signaling cascade that evokes biological responses (Wouters et al., 2011)

5.5 Divergent roles of HO-1 in ferroptosis: between protection and promotion Although numerous studies have suggested that HO-1 may exert neuroprotective effects in VaD by regulating ferroptosis, an in-depth analysis of the existing literature reveals that the findings are not entirely consistent

& Mondal, A

Brning, T