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Collectively, these findings highlight lipid-related PTMs as critical DDR regulators and potential therapeutic targets in cancer

Upon activation, proapoptotic proteins form pore complexes on the mitochondrial membrane, resulting in the loss of the mitochondrial membrane potential and the release of apoptotic factors such as cytochrome C, thereby activating the caspase-9/3 cascade [46]

Grx1 is known to inhibit apoptotic cell death through regulating multiple targets, such as AKT and JNK []

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Omega-3 fatty acids, which was proven to reduce SLE activity, should also be considered in addition to the conventional regimens used for SLE (173)

Tocopherol (Vitamin E): A powerful antioxidant that protects against free radical damage