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10.1038/s41537-017-0037-1 146 OngW

The Zn 2+ ion plays a structural role and is required for an efficient SOD1 folding and long-term stability 2 , whereas active-site Cu 2+ catalyzes O 2 dismutation by alternating between the reduced and oxidized states (Reactions 1 and 2): In the nervous tissue, SOD1 is present at exceedingly high concentrations (~1% of total protein, i.e., 100200 M) 3 and is traditionally regarded as cytosolic protein 4

i-j , Fluorescence histograms of FSP1 GFP-P2A-BFP cells grown in normal or vitamin B2-deficient medium for 72 h showing changes in GFP:BFP ratio ( i ) or GFP and BFP fluorescence ( j )

Some tannins catabolites of the gut microbiota may have prebiotic activity, such as urolithin produced by pomegranate ellagitannins, which in preclinical studies has actively regulated lactic bacteria, Bifidobacteria and enterobacteria model of intestinal inflammation in rats (55)

Chin J Pathophysiol (2014) 30(6):111097

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