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Kelgane SB, Salve J, Sampara P, Debnath K

4 Disorders of immune metabolic pathways in sepsis 4.1 Key components and mechanisms of lung immunity The lung is the only internal organ in the human body that is in direct contact with the external environment continuously (17)

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This AOP identifies the deposition of ionizing energy as the MIE, leading to DSB and subsequent mutations due to the errors in DNA repair mechanisms

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Yet, this mechanism may be more difficult to target, as cells can also redirect to the PPP pathway, creating less dependency on serine and glycine metabolism