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This reduction in cytokine release likely occurs due to inhibited NF-B signalling, as intermediates of the NF-B pathway such as phosphorylated p-65 and phosphorylated NF-B are decreased upon Hcar2 agonism [81, 82]

doi: 10.1016/j.joca.2023.01.573 167 GuoPGaoXNelsonALHuardMLuAHambrightWSet al

The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation

Cell 143 , 10841096 (2010)

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When compared to matched normal thyroid tissue, both benign (human follicular adenomas, or FTAs) and malignant (follicular (FTC) and papillary thyroid carcinoma (PTC)) lesions were found to have elevated nuclear levels of 8-oxo-dG (118) which most likely reflects the detrimental effects of prolonged exposure to chronic OxS seen during thyroid cancer (113, 118)