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Thus, the inhibition of antioxidant enzymes in this pathway also contributes to oxidative stress

All these results allowed to conclude that APR-246 induces early cell death by ferroptosis, a recently described non-apoptotic form of regulated cell death that links together membrane lipid peroxidation, cysteine and iron metabolism, glutathione peroxidase activity and oxidative stress (as summarized in Figure 4A 2325 )

10.1016/j.nrleng.2023.05.002 69 KimY.ChaS

Sern, AnnaKaisa Tuomaala, Johan Jendle, Pratik Choudhary, Emanuele Bosi, Viswanathan Mohan, Tim van den Heuvel, Ohad Cohen, Richard F

Creatine monohydrate is non-enzymatically converted to creatinine in skeletal muscle, and supplementation at standard 3 to 5 g per day doses reliably elevates serum creatinine 1

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